Ototoxicity of colistin sodium methanesulfonate (CLM).
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of colistin in cerebrospinal fluid after intraventricular administration of colistin methanesulfonate.
Intraventricular colistin, administered as colistin methanesulfonate (CMS), is the last resource for the treatment of central nervous system infections caused by panresistant Gram-negative bacteria. The doses and daily regimens vary considerably and are empirically chosen; the cerebrospinal fluid (CSF) pharmacokinetics of colistin after intraventricular administration of CMS has never been char...
متن کاملAssay of colistin and colistin methanesulfonate in plasma and urine by liquid chromatography-tandem mass spectrometry.
A rapid high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed for the routine quantification of colistins A and B and their prodrugs, colistin methanesulfonate (CMS) A and CMS B, respectively, in human plasma and urine by using polymyxin B1 as the internal standard (IS). CMS concentrations were determined indirectly by subtracting the colistin concentrat...
متن کاملPharmacokinetics of colistin methanesulfonate and colistin in a critically ill patient receiving continuous venovenous hemodiafiltration.
Intravenous colistin methanesulfonate (CMS) is increasingly the last line of defense for multidrug-resistant gram-negative bacteria and is now being used as “salvage” therapy in critically ill patients (1, 7, 9, 11). CMS is converted in vivo to colistin, and these two entities have substantially different pharmacokinetics, antibacterial activities, and toxicities (7), and therefore it is import...
متن کاملPopulation pharmacokinetics of colistin methanesulfonate in rats: achieving sustained lung concentrations of colistin for targeting respiratory infections.
Colistin methanesulfonate (CMS), the inactive prodrug of colistin, is administered by inhalation for the management of respiratory infections. However, limited pharmacokinetic data are available for CMS and colistin following pulmonary delivery. This study investigates the pharmacokinetics of CMS and colistin following intravenous (i.v.) and intratracheal (i.t.) administration in rats and deter...
متن کاملPharmacokinetics of colistin methanesulfonate and formed colistin in end-stage renal disease patients receiving continuous ambulatory peritoneal dialysis.
Colistin, administered intravenously as its inactive prodrug colistin methanesulfonate (CMS), is increasingly used as last-line therapy to combat multidrug-resistant Gram-negative bacteria. CMS dosing needs to be adjusted for renal function. The impact of continuous ambulatory peritoneal dialysis (CAPD) on the pharmacokinetics of both CMS and colistin has not been studied. No CMS dosing recomme...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1980
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)53688-5